Divisions of the SCRC
Our lab features a number of divisions researching different aspects and uses of stem cells. Click on one of the links below to go to a page on that division.
- Growth and Development Laboratory
The Growth and Development Lab is run by Dr. Huard and has several sub-labs, each with a specific focus:
- Endothelial/Vascular/Adipose Cells
The EVA Cells Lab focuses on the characterization of mouse and human stem cells, including the identification of a novel marker and the development of new assays for human stem cells in immunodeficient mice. The laboratory studies the ontogeny of the blood and vascular systems, and also approaches the development and regeneration of other tissues and organs, including skin, airway, and lymph nodes.
- Molecular Therapeutics
The Molecular Therapy Laboratory, under the direction of Dr. Bing Wang, has focused on the virology of adeno-associated virus (AAV) and its utility as a promising vector system for gene therapy approaches targeting muscle, joint, bone, and cartilage.
- Clinical Translation/Rehabilitation
The CTRL’s main focus is to identify critical barriers to the clinical translation of musculoskeletal research efforts investigated within the SCRC, and to develop methods for overcoming these barriers. It is run by Dr. Fabrisia Ambrosio and Dr. Vonda Wright.
- Stem Cell Ecology and Cancer
The Stem Cell Ecology and Cancer Lab concentrates its efforts on four main areas of research: investigating how the balance of intrinsic and extrinsic signaling affects stem cell differentiation and transformation; assessing the contributions of the environment (host) and microenvironment in tumorigenesis (examining immune system involvement in the transformation of stem cells as well as the effect of tumorigenesis on the host); translation of the knowledge gained from this work into validating therapeutic targets by developing approaches to condition the environment to retard tumorigenesis and tumor metastasis; iv) to use stem/progenitor cells to model human tumors.
- Molecular Pathology Laboratory
Many staff members work in this lab. The purpose of the lab is to examine adult stem cells, such as those of skin and muscle, as a tool to repair injured and congenitally diseased tissues (muscle, tendon, spinal cord, and others) and determine the potency and viability of various potential dedifferentiation stimulating compounds in vitro and in vivo; and to determine the mechanism(s) behind dedifferentiation in amphibians, and ascertain the relationship(s) between dedifferentiation and fibrotic scar tissue formation.
- Pediatric Craniofacial Biology Laboratory
- Live Cell Imaging
The Live Cell Imaging lab is run by Dr. Bridget M. Deasy. She maintains a Live Cell Imaging website here.